The Ospreys will welcome the Dragons to the Liberty Stadium on Saturday 23rd March (3pm KO) and tickets for the game will be available to buy from Friday (17th January) at noon.
The Guinness PRO14 Round 18 fixture was confirmed today, as part of the announcement of Rounds 18-21, the earliest ever that the full season schedule has been finalised.
The Dragons clash is the final home game of the season with the remaining three rounds in April all on the road.
The team are in South Africa for Rounds 19 and 20. They head to Bloemfontein to play Toyota Cheetahs at Toyota Stadium on Saturday 6th April (5.30pm KO Local Time). The following weekend will see a first-ever away game versus Isuzu Southern Kings on Friday 12th April at 7.35pm.
The final round of the season sees all four Welsh Regions head to Principality Stadium for Judgment Day, the Ospreys facing Cardiff Blues at 5.15pm on Saturday 27th April.
Supporters will be able to purchase tickets for the Dragons game from Friday at noon at www.ospreysrugby.com/buytickets - Judgment Day tickets are already available at the same link.