In Wayne Pivac's inaugural Six Nations campaign, the former Scarlets and Fiji head coach has selected five Ospreys in his 38-man squad.
Three of the five come from the pack, with Adam Beard and Alun Wyn Jones representing the second row, with the latter selected once more to lead the side. Ospreys captain Justin Tipuric is among the rich back row selection.
In the backs, Owen Watkin, who has recently re-signed for the Ospreys, makes a timely return to international duties; and winger George North, who made a start at centre against Saracens over the weekend, gives Pivac a powerful running proposition in the wide channels.
"We are really excited to be naming our Six Nations squad and kicking the campaign off," said Wales head coach Wayne Pivac.
"A lot of time and effort has gone into selecting the squad, all of the coaches have been out and about, seeing players in training, speaking with them and we are pretty excited with the group we have got.
Wales Six Nations 2020 squad
Forwards: Rhys Carre, Rob Evans, Wyn Jones, Elliot Dee, Ryan Elias, Ken Owens, Leon Brown, WillGriff John, Dillon Lewis, Jake Ball, Adam Beard, Seb Davies, Alun Wyn Jones (captain), Will Rowlands, Cory Hill, Aaron Shingler, Aaron Wainwright, Taulupe Faletaau, Ross Moriarty, Josh Navidi, Justin Tipuric
Backs: Gareth Davies, Rhys Webb, Tomos Williams, Dan Biggar, Owen Williams, Jarrod Evans, Hadleigh Parkes, Nick Tompkins, Owen Watkin, George North, Josh Adams, Owen Lane, Johnny Mcnicholl, Louis Reez-Zammit, Jonah Holmes, Leigh Halfpenny, Liam Williams