Jac Morgan is set to lead the side out for the first time since being appointed captain for the 24/25 season.
Gareth Thomas starts at loosehead, with Dewi Lake lining up at hooker and Tom Botha completing the front three.
James Ratti partners with Adam Beard at lock. Jac Morgan lines up at six, Justin Tipuric takes up the other flank and Morgan Morris starts at eight.
Reuben Morgan-Williams starts at scrum half, with Dan Edwards partnering him at 10. Keiran Williams and Owen Watkin get the nod in the centres.
In the back three, Jack Walsh starts at full back, with Ryan Conbeer on one wing and Luke Morgan on the other.
Conbeer will make his competitive debut, with three other potential debutants on the bench.
Starting XV:
15. Jack Walsh
14. Luke Morgan
13. Owen Watkin
12. Keiran Williams
11. Ryan Conbeer
10. Dan Edwards
9. Reuben Morgan-Williams
1. Gareth Thomas
2. Dewi Lake
3. Tom Botha
4. James Ratti
5. Adam Beard
6. Jac Morgan ©
7. Justin Tipuric
8. Morgan Morris
Replacements:
16. Lewis Lloyd
17. Steffan Thomas
18. Math Iowerth-Scott
19. Huw Sutton
20. Harri Deaves
21. Luke Davies
22. Phil Cokanasiga
23. Max Nagy
Head Coach, Toby Booth, said: “Dragons away hasn’t been a great game for us in the last two years. This fixture has a common theme of discipline in both sets of fixtures, which normally favours the home team. If you want to win a Welsh derby, especially away from home, you have to keep your players on the pitch.”
