Jac Morgan is set to captain the side.
Steffan Thomas gets his first competitive start for the Ospreys at loosehead, with Dewi Lake lining up at hooker and Tom Botha completing the front three.
Huw Sutton partners with Adam Beard at lock. James Ratti lines up at six, Jac Morgan takes up the other flank and Morgan Morris starts at eight.
Reuben Morgan-Williams starts at scrum half with Dan Edwards partnering him at 10, as the pair look to continue their strong start to the season. Phil Cokanasiga gets his first BKT URC start with Owen Watkin lining up outside him.
In the back three, Max Nagy starts at full back, with Ryan Conbeer on one wing and Iestyn Hopkins on the other.
Sam Parry also returns to the fold and takes up a place on the bench.
Starting XV:
15. Max Nagy
14. Iestyn Hopkins
13. Owen Watkin
12. Phil Cokanasiga
11. Ryan Conbeer
10. Dan Edwards
9. Reuben Morgan-Williams
1. Steffan Thomas
2. Dewi Lake
3. Tom Botha
4. Huw Sutton
5. Adam Beard
6. James Ratti
7. Jac Morgan ©
8. Morgan Morris
Replacements:
16. Sam Parry
17. Garyn Phillips
18. Ben Warren
19. Lewis Jones
20. Harri Deaves
21. Luke Davies
22. Jack Walsh
23. Keiran Williams
First Team Coach, Richard Kelly, said: “Munster will be hurting after their result last week, but we’ve never been to Munster without them flying out the gates. We know the level of collision, skillset and challenge they’ll bring, but for us it’s about improving our performances week in, week out.”
